NIMG-11. THE EXTENT OF NECROSIS IN BRAIN METASTASES MAY PREDICT SUBTYPES OF PRIMARY CANCER AND OVERALL SURVIVAL IN PATIENTS RECEIVING CRANIOTOMY

Abstract Although necrosis is common in brain metastasis (BM), its biological and clinical significances remain unknown. We evaluated extent differences by primary cancer subtype correlated BM to overall survival post craniotomy. analyzed 145 patients receiving Necrosis tumor ratio (NTR) was measured. Patients were divided into two groups NTR: BMs with sparse abundant necrosis. Clinical features compared. To investigate factor relevance for necrosis, multivariate logistic regression, random forests, gradient boosting machine analyses performed. Kaplan–Meier analysis log-rank tests performed evaluate the effect of on survival. Lung a more origin (42/72, 58.33%) versus (23/73, 31.51%, p< 0.01). Primary volume most relevant factors (p< harboring moderately showed longer survival, or highly (p=0.03). may carry larger than from other cancers. Further, predict good prognosis